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Description of Individual Course Units


Course Unit Code Course Unit Title Type of Course Unit Year of Study Semester Number of ECTS Credits
BKM2401 BIOPROCESS KINETICS 4 7 5,00

Lisans


English


The main objective of this course is to give students a deep understanding of bio-processes—how they operate and how they are designed.and modeling and control.



1 Know how to make use of stoichiometric information,
2 Learn to perform elemental material balances, and estimate yield coefficients
3 Explain how and why cell, product and substrate concentrations change in batch cultures
4 Learn what the specific growth rate, specific product formation rate
5 Define rate expressions for cell growth, for product formation given the growth conditions
6 Explain the differences in rate expressions for cell growth and for product formation
7 Recognize the limitations of growth and of product formation
8 Demonstrate the ability to write down a rate expression for a given data set and solve it
9 Compute the specific growth rate, the specific product formation rate
10 Demonstrate the ability to combine cell growth and product formation data to find substrate utilization
11 Learn how to apply yield coefficient information to define substrate utilization
12 Organize the content of a document according to the informational needs and technical background of audience
13 Communicate facts supported by evidence and/or sufficiently detailed explanation
14 Submit written work without errors in spelling, punctuation, and usage
15 Understand the social, cultural, political and environmental impacts of biotechnological practice
16 Independently research scientific literature and related references
17 Understand the role Biochemist in Biotechnology in addressing societal challenges


None


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Introduction, Cell quantification, Models, Exponential growth model, The Monod model, Yield coefficients, productivity, Modelling fermentation processes, Chemostat cultures


Week Subjects (Theoretical) Teaching Methods Preparatory
1 Introduction to Bioprocess Kinetics
2 Estimation of Biomass
3 Stoichiometry
4 Mathematical Models
5 Microbial Growth: Effect of Inhibition and Activation of Growth and Growth Rate Analysis
6 A Simple Model of a Fermentation Process:Batch Culture
7 Problem solving
8 Mid-term Exam
9 Product Formation in Microbial Cultures
10 Chemostat Culture: Elaboration of Chemostat
11 A mathematical Model of a Chemostat
12 Plug Flow Culture
13 Fed-Batch Culture
14 Problem solving
15 Project presentation
16 Final Exam

M. L. Schuler, F. Kargi, “Bioprocess Engineering”, Prentice Hall Int. Series, (2002) H. W. Blanch D.S. Clark, “Biochemical Engineering”, Marcel Dekker, (1997) C. Radledge, B. Kristiansen, “Basic Biotechnology” Second Edition,. Cambridge University Press, (2001) J. E. Bailey, D. F. Ollis, “Biochemical Engineering Fundamentals” Second Edition, Mc Graw Hill International, (1986) N. S. Panikov, “Microbial Growth Kinetics” First Edition, Chapman & Hall, (1995)


Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"


Term (or Year) Learning Activities Quantity Weight
Midterm Examination 1 80
Project Preparation 1 10
Project Presentation 1 10
Total 100
End Of Term (or Year) Learning Activities Quantity Weight
Final Examination 1 100
Total 100
Term (or Year) Learning Activities 40
End Of Term (or Year) Learning Activities 60

None


Activities Number Time (hours) Total Work Load (hours)
Midterm Examination 1 2 2
Final Examination 1 2 2
Tutorial 14 2 28
Problem Solving 3 3 9
Project Preparation 2 4 8
Project Presentation 2 4 8
Self Study 7 1 7
Individual Study for Mid term Examination 1 5 5
Individual Study for Final Examination 1 15 15
Reading 2 4 8
Total Work Load (hours) 92

PO 1 PO 2 PO 3 PO 4 PO 5 PO 6 PO 7 PO 8 PO 9 PO 10 PO 11 PO 12 PO 13 PO 14 PO 15
LO 1 5 5 5 5 5 4
LO 2 5 5 5 5 5 4
LO 3 5 5 5 5 5 4
LO 4 5 5 5 5 5 4
LO 5 5 5 5 5 5 4
LO 6 5 5 5 5 5 4
LO 7 5 5 5 5 5 4
LO 8 5 5 5 5 5 4
LO 9 5 5 5 5 5 4
LO 10 5 5 5 5 5 5 4
LO 11 5 5 5 5 5 4
LO 12 5 4
LO 13 5 5 4 4
LO 14 5 5 5
LO 15 5 5 5
LO 16 5 5 5
LO 17 4 5 5 5
* Contribution Level: 1 Very low 2 Low 3 Medium 4 High 5 Very High