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Description of Individual Course Units
| Course Unit Code | Course Unit Title | Type of Course Unit | Year of Study | Semester | Number of ECTS Credits |
|---|---|---|---|---|---|
| BKM2401 | BIOPROCESS KINETICS | 4 | 7 | 5,00 |
Level of Course Unit
Lisans
Language of Instruction
English
Objectives of the Course
The main objective of this course is to give students a deep understanding of bio-processes—how they operate and how they are designed.and modeling and control.
Name of Lecturer(s)
Learning Outcomes
| 1 | Know how to make use of stoichiometric information, |
| 2 | Learn to perform elemental material balances, and estimate yield coefficients |
| 3 | Explain how and why cell, product and substrate concentrations change in batch cultures |
| 4 | Learn what the specific growth rate, specific product formation rate |
| 5 | Define rate expressions for cell growth, for product formation given the growth conditions |
| 6 | Explain the differences in rate expressions for cell growth and for product formation |
| 7 | Recognize the limitations of growth and of product formation |
| 8 | Demonstrate the ability to write down a rate expression for a given data set and solve it |
| 9 | Compute the specific growth rate, the specific product formation rate |
| 10 | Demonstrate the ability to combine cell growth and product formation data to find substrate utilization |
| 11 | Learn how to apply yield coefficient information to define substrate utilization |
| 12 | Organize the content of a document according to the informational needs and technical background of audience |
| 13 | Communicate facts supported by evidence and/or sufficiently detailed explanation |
| 14 | Submit written work without errors in spelling, punctuation, and usage |
| 15 | Understand the social, cultural, political and environmental impacts of biotechnological practice |
| 16 | Independently research scientific literature and related references |
| 17 | Understand the role Biochemist in Biotechnology in addressing societal challenges |
Mode of Delivery
Prerequisities and Co-Requisities
None
Recommended Optional Programme Components
None
Content of the Course
Introduction, Cell quantification, Models, Exponential growth model, The Monod model, Yield coefficients, productivity, Modelling fermentation processes, Chemostat cultures
Weekly Detailed Course Contents
| Week | Subjects (Theoretical) | Teaching Methods | Preparatory |
|---|---|---|---|
| 1 | Introduction to Bioprocess Kinetics | ||
| 2 | Estimation of Biomass | ||
| 3 | Stoichiometry | ||
| 4 | Mathematical Models | ||
| 5 | Microbial Growth: Effect of Inhibition and Activation of Growth and Growth Rate Analysis | ||
| 6 | A Simple Model of a Fermentation Process:Batch Culture | ||
| 7 | Problem solving | ||
| 8 | Mid-term Exam | ||
| 9 | Product Formation in Microbial Cultures | ||
| 10 | Chemostat Culture: Elaboration of Chemostat | ||
| 11 | A mathematical Model of a Chemostat | ||
| 12 | Plug Flow Culture | ||
| 13 | Fed-Batch Culture | ||
| 14 | Problem solving | ||
| 15 | Project presentation | ||
| 16 | Final Exam |
Text Book / Material / Recommended Resources
M. L. Schuler, F. Kargi, “Bioprocess Engineering”, Prentice Hall Int. Series, (2002) H. W. Blanch D.S. Clark, “Biochemical Engineering”, Marcel Dekker, (1997) C. Radledge, B. Kristiansen, “Basic Biotechnology” Second Edition,. Cambridge University Press, (2001) J. E. Bailey, D. F. Ollis, “Biochemical Engineering Fundamentals” Second Edition, Mc Graw Hill International, (1986) N. S. Panikov, “Microbial Growth Kinetics” First Edition, Chapman & Hall, (1995)
Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"
Assessment Methods and Criteria
| Term (or Year) Learning Activities | Quantity | Weight |
|---|---|---|
| Midterm Examination | 1 | 80 |
| Project Preparation | 1 | 10 |
| Project Presentation | 1 | 10 |
| Total | 100 | |
| End Of Term (or Year) Learning Activities | Quantity | Weight |
| Final Examination | 1 | 100 |
| Total | 100 | |
| Term (or Year) Learning Activities | 40 | |
| End Of Term (or Year) Learning Activities | 60 | |
Work Pacement(s)
None
Workload Calculation
| Activities | Number | Time (hours) | Total Work Load (hours) |
|---|---|---|---|
| Midterm Examination | 1 | 2 | 2 |
| Final Examination | 1 | 2 | 2 |
| Tutorial | 14 | 2 | 28 |
| Problem Solving | 3 | 3 | 9 |
| Project Preparation | 2 | 4 | 8 |
| Project Presentation | 2 | 4 | 8 |
| Self Study | 7 | 1 | 7 |
| Individual Study for Mid term Examination | 1 | 5 | 5 |
| Individual Study for Final Examination | 1 | 15 | 15 |
| Reading | 2 | 4 | 8 |
| Total Work Load (hours) | 92 | ||
Contribution of Learning Outcomes to Programme Outcomes
| PO 1 | PO 2 | PO 3 | PO 4 | PO 5 | PO 6 | PO 7 | PO 8 | PO 9 | PO 10 | PO 11 | PO 12 | PO 13 | PO 14 | PO 15 | |
| LO 1 | 5 | 5 | 5 | 5 | 5 | 4 | |||||||||
| LO 2 | 5 | 5 | 5 | 5 | 5 | 4 | |||||||||
| LO 3 | 5 | 5 | 5 | 5 | 5 | 4 | |||||||||
| LO 4 | 5 | 5 | 5 | 5 | 5 | 4 | |||||||||
| LO 5 | 5 | 5 | 5 | 5 | 5 | 4 | |||||||||
| LO 6 | 5 | 5 | 5 | 5 | 5 | 4 | |||||||||
| LO 7 | 5 | 5 | 5 | 5 | 5 | 4 | |||||||||
| LO 8 | 5 | 5 | 5 | 5 | 5 | 4 | |||||||||
| LO 9 | 5 | 5 | 5 | 5 | 5 | 4 | |||||||||
| LO 10 | 5 | 5 | 5 | 5 | 5 | 5 | 4 | ||||||||
| LO 11 | 5 | 5 | 5 | 5 | 5 | 4 | |||||||||
| LO 12 | 5 | 4 | |||||||||||||
| LO 13 | 5 | 5 | 4 | 4 | |||||||||||
| LO 14 | 5 | 5 | 5 | ||||||||||||
| LO 15 | 5 | 5 | 5 | ||||||||||||
| LO 16 | 5 | 5 | 5 | ||||||||||||
| LO 17 | 4 | 5 | 5 | 5 |
* Contribution Level: 1 Very low 2 Low 3 Medium 4 High 5 Very High